GENART Technologies, Inc.
Harry F. Crevecoeur, MD
Valley Stream, New York 11582-0430
Phone: (646) 373-9624 Fax: (516)706-7781
August 30, 2003
President George W. Bush, First Lady Laura Bush, Fmr. Pres. Bill Clinton, Sen. Hillary Rodham-Clinton, fmr. Pres. Nelson Mandela, Mr. & Mrs. Kofi Anan, Sen. Charles Schumer, Sen. Bill Fritz, Sen. Martin M. Dilan, Dr. Bruce Agins, Dr. Benny Primm, Dr. Jack Whitescarver, Dr. Louis W. Sullivan, Dr. Lee Jong-Wook, Mayor Michael Bloomberg, Gov. George Pataki, Congressman Charles B. Rangel, Congressmen Major Owens and Edolphus Towns, Mr. Phillip Reed, Ms. Tracy Boyland, Mr. & Mrs. Bill Gates, Dr. William Foege, Ms. Oprah Winfrey, Queen Latifah, Mr. Ervin (Magic) Johnson, Ms. Elizabeth Taylor, Ms. Barbara Streisand, Ms. Mary Fisher, U2’s Bono, Mr. Bill Cosby, Mr. Michael Jackson, Mr. Danny Glover, Mr. Elton John, Ms. Ana Oliveira, Pope John Paul II, Cardinal E. Egan, Rev. Billy Graham, Rev. Jamil Georgeon, Rev. Al Sharpton, Rev. Alphonso R. Bernard, Mr. Kweisi Mfume, Mr. Paul A. Allaire, Ms. Jeanne White-Ginder, US Senate, US House of Representatives, NY City Council.
Re: HIV Vaccine
Dear Friends and Elected Officials:
I am writing this letter to ask for your support to help finalize the pre-clinical studies for a truly noble research project that I strongly believe will lead to a “cure” for HIV. We stress the words “cure” for HIV as opposed to chronic management of the potentially deadly virus. At GENART Technologies, Inc., we designed an HIV vaccine which is expected to be effective, safe, affordable, preventative and therapeutic. An important part of our mission is to keep the final cost of this life saving vaccine affordable. It is our hope that with your support we can have this ideal HIV vaccine developed in an accelerated project.
While we all share a sharp eagerness to witness a cure for HIV, we tend to retreat our hope to no more than a guarded optimism. Such a position is indeed justifiable, considering all the unsuccessful struggles our scientific communities have so far endured. Although I respect any skepticism which may dominate your impressions at this time, please, allow me to invite you to accept the notion that, yes, a CURE for HIV is indeed, possible and now finally in sight. We pursued our research in a radically different direction than previously attempted, focusing on the 3-dimensional relationships of HIV protein molecules, rather than their linear sequences.
My name is Harry F. Crevecoeur, MD, President and Founder of the GENART Technologies, Inc. I am board-certified in both Internal Medicine and Infectious Disease – currently practicing at Kings County Hospital and two Family Care Centers in Brooklyn, N.Y. (East New York D&TC and Brownsville Multi-Service Family Care Center) where I care for HIV-infected patients. My research in the field of HIV vaccines since 1995, has led to a vaccine design based on a novel SSSP strategy (Surface Simulation Synthetic Peptides), which is currently under review at the US Patent Office (www.uspto.gov) since December 2001 and recently submitted for publication.
Our HIV vaccine design takes a significantly different approach than previously attempted. Instead of focusing on the linear sequences of protein molecules, our design focuses on conserved 3-Dimensional configurations of key HIV protein molecules. This is the only strategy so far that can overcome the high mutation rate of the virus.
The immune system generally targets proteins (e.g. proteins from bacteria or viruses) by recognizing their linear sequences. All previously attempted vaccines so far have been designed to target linear sequences. While these strategies may work for targets that remain constant, they fail to neutralize HIV because the linear sequences of HIV mutate faster than the immune system can respond. Most HIV vaccines tested to date fail because they target linear sequences, thereby duplicating what the immune system is already doing and failing. What I have found is that the conserved (constant) entity for HIV lies primarily in the 3-Dimensional Configuration of its protein molecules and not in their linear sequences. The new direction of my research has been to strategize an attack against the HIV virus by addressing those unique (unchanged or conserved) 3-D relationships.